A case of chronic myeloid leukemia with the m-bcr (p190) molecular rearrangement identified during treatment
نویسندگان
چکیده
hronic myeloid leukemia (CML) is a hematological maligancy in which a high percentage of patients cytogenetically xpress the Philadelphia chromosome. This chromosome esults from the reciprocal translocation, t(9;22)(q34;q11.2). uring this exchange, the Abelson gene (abl) on chromosome and the breakpoint cluster region gene (bcr) on chromosome 2 generate the breakpoint cluster region-Abelson murine eukemia (BCR-ABL) fusion gene. The most frequent breakoint on chromosome 22, located between exons 12 and 16, s called the major breakpoint cluster region (M-bcr) and with ts counterpart in exon 2 of chromosome 9 results in the b2a2 nd b3a2 transcripts that code for a 210 kDa protein. Less freuently, a second rearrangement, minor breakpoint cluster
منابع مشابه
BCR-ABL fusion genes and laboratory findings in patients with chronic myeloid leukemia in northeast Iran
Background: A specific chromosomal abnormality, the Philadelphia chromosome (BCR-ABL fusion), is present in all patients with chronic myeloid leukemia (CML). The b2a2 and b3a2 fusion mRNAs encode p210 fusion protein p210 and e1a2 encode p190. The aim of this study was to evaluate the frequency of BCR-ABL fusion transcript variants in Northeast of Iranian CML patients and to compare the laborato...
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